...

FLIX FLow chemistry for Isotopic eXchange

FLIX is making the creation of isotope-labelled molecules easier, faster, and more effective with new generations of catalysts for isotope exchange along with flow chemistry. Success will have tremendous impact on fields from synthetic chemistry to biomedical diagnostics to materials research.

The ‘FLIX machinery’ will use a combination of specialized reactor modules operating under continuous flow conditions, either in closedloop or open systems for the on-line H/D, C-12/C-13, N-14/N-15 and methoxy group direct isotopic exchanges with an unprecedented efficacy and without any chemical alteration of the molecules.

The project’s objectives are to:

1) develop new generations of organometallic catalysts for isotopic exchange reactions;

2) screen catalysts for the isotopic exchange on a relevant portfolio of organic molecules in batch and flow chemistries and assess catalyst robustness;

3) devise and validate the ‘combinable isotope labeling’ concept;

4) design and build an adaptable multi-module machinery for combinable chemical exchange labeling.

FLIX synergistically associates the expertise and innovation potential of a mixed academic/industrial multidisciplinary consortium. The project is expected to have a multi-billion Euro positive impact on all sectors using stable isotopes in particular:

1) drug innovation, by accelerating preclinical studies, de-risking clinical trials and fostering the development of novel deuterated ‘heavy drugs’;

2) design of new tracers for diagnostic imaging with improved biological properties;

3) streamlining the production of multi-labeled complex molecules for NMR studies;

4) the development of novel isotopically-enriched materials.

partners / contact

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

[ CEA ]

France

SOPHIE FEUILLASTRE

SOPHIE FEUILLASTRE

National Institute of Applied Sciences of Toulouse

[ INSAT ]

France

BRUNO CHAUDRET

BRUNO CHAUDRET

Leibniz Institute of Catalysis

[ LIKAT ]

Germany

MATTHIAS BELLER

MATTHIAS BELLER

Aarhus University

[ AU ]

Denmark

TROELS SKYDSTRUP

TROELS SKYDSTRUP

ComInnex

[ COMINNEX ]

Hungary

GELLERT SIPOS

GELLERT SIPOS

Absiskey

[ ABSISKEY ]

France

Samy STROLA

Samy STROLA

Universiteit van Amsterdam

[ UVA ]

The Netherlands

TIMOTHY NOEL

TIMOTHY NOEL

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 862179 . This publication [communication] reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

graph - chart

Start 01/01/2020
25% 06/12/2020
End 31/12/2023
Budget allocation . M€ Budget allocation
Effort 493 p*m Effort
Effort 10 persons Full time equivalent

news

Publication Flow chemistry experiments in the...

2020-10-08

Discover this new scientific article about " Flow chemistry experiments in the undergraduate teaching laboratory: synthesis of dia...

View more

Institute of Life Sciences Frédéric Joliot ...

2020-10-06

Institute of Life Sciences Frédéric Joliot (CEA) talked about launch of FLIX, a European project for the isotopic labelin...

View more

Scientific Paper about " Hydrogen Isotope Exc...

2020-10-01

Discover a new Scientific Paper about the following subject : " Hydrogen Isotope Exchange Catalyzed by Ru Nanocatalysts: Labelling...

View more

Scientific Paper about " Hydrogen Isotope Exc...

2020-10-01

Discover a new Scientific Paper about the following subject : " Hydrogen Isotope Exchange Catalyzed by Ru Nanocatalysts: Labelling...

View more

FLIX at Nanocatalysis for Hydrogen Isotope Ex...

2020-09-17

On September 17, 2020, the Conference about Nanocatalysis for Hydrogen Isotope Exchange was held at Paris-Saclay University (ICSN).This conf...

View more

ACS Fall 2020 Virtual Meeting & Expo

2020-08-17

The Flix partners attended to the ACS Fall 2020 Virtual Meeting & Expo Conference which took place from August 17 to Augu...

View more

Abstract published for ACS Fall 2020 Virtual ...

2020-08-17

As you know, Flix project was in August at ACS Fall 2020 Virtual Meeting & Expo Conference. In the following link, you'll find ...

View more

Kick-Off Meeting

2020-01-30

The kick-off meeting of FLIX project took place in Paris, on January 30, at CEA’s headquarters.
 The FLIX project, fund...

View more

events

2020-09-17

Nanocatalysis for Hydrogen Isotope Exchange Conference (2020)

The Conference about Nanocatalysis for Hydrogen Isotope Exchange was held at Paris-Saclay University (ICSN) by Gregory Pieters (CEA).

2020-08-17

ACS Fall 2020 Virtual Meeting & Expo

Giving scientific professionals a platform to present, publish, discuss and exhibit the most exciting research discoveries and technologies in chemistry and its related disciplines. The meeting will facilitate networking opportunities, career development and placement, and provide companies an opportunity to exhibit products and services to a targeted audience.

documents

Flow chemistry experiments in the undergraduate teaching laboratory synthesis of diazo dyes and disulf

Hydrogen Isotope Exchange Catalyzed by Ru Nanocatalysts: Labelling of Complex Molecules Containing N‐Heterocycles and Reaction Mechanism Insights

Newsletter - Institute of Life Sciences Frédéric Joliot (CEA) - Informations about Flix project

contact us

By submitting this form, I agree that the information entered may be used for newsletter subscriptions, information requests and statistical analysis that may result. Under no circumstances will these data be transferred to third parties.
To know and exercise your rights, in particular to withdraw your consent to the use of data collected by this form, please consult our general conditions of use.

project netboard login

project netboard login