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FLIX FLow chemistry for Isotopic eXchange

FLIX is making the creation of isotope-labelled molecules easier, faster, and more effective with new generations of catalysts for isotope exchange along with flow chemistry. Success will have tremendous impact on fields from synthetic chemistry to biomedical diagnostics to materials research.

The ‘FLIX machinery’ will use a combination of specialized reactor modules operating under continuous flow conditions, either in closedloop or open systems for the on-line H/D, C-12/C-13, N-14/N-15 and methoxy group direct isotopic exchanges with an unprecedented efficacy and without any chemical alteration of the molecules.

 

The project’s objectives are to:

1) develop new generations of organometallic catalysts for isotopic exchange reactions;

2) screen catalysts for the isotopic exchange on a relevant portfolio of organic molecules in batch and flow chemistries and assess catalyst robustness;

3) devise and validate the ‘combinable isotope labeling’ concept;

4) design and build an adaptable multi-module machinery for combinable chemical exchange labeling.

 

FLIX synergistically associates the expertise and innovation potential of a mixed academic/industrial multidisciplinary consortium. The project is expected to have a multi-billion Euro positive impact on all sectors using stable isotopes in particular:

1) drug innovation, by accelerating preclinical studies, de-risking clinical trials and fostering the development of novel deuterated ‘heavy drugs’;

2) design of new tracers for diagnostic imaging with improved biological properties;

3) streamlining the production of multi-labeled complex molecules for NMR studies;

4) the development of novel isotopically-enriched materials.

 
We look forward to begin the second year of the project with renovated strength and commitment.

partners / contact

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

[ CEA ]

France

SOPHIE FEUILLASTRE

SOPHIE FEUILLASTRE

National Institute of Applied Sciences of Toulouse

[ INSAT ]

France

BRUNO CHAUDRET

BRUNO CHAUDRET

Additional contact person: Dr. Guy Lippens, glippens@insa-toulouse.fr, Toulouse Biotechnology Institute Bio & Chemical Engineering

Leibniz Institute of Catalysis

[ LIKAT ]

Germany

MATTHIAS BELLER

MATTHIAS BELLER

Aarhus University

[ AU ]

Denmark

TROELS SKYDSTRUP

TROELS SKYDSTRUP

X-CHEM

[ X-CHEM ]

Hungary

GELLERT SIPOS

GELLERT SIPOS

Absiskey

[ ABSISKEY ]

France

Lauren DELAGE

Lauren DELAGE

Universiteit van Amsterdam

[ UVA ]

The Netherlands

TIMOTHY NOEL

TIMOTHY NOEL

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 862179 . This publication [communication] reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

graph - chart

Start 01/01/2020
100%
End 30/06/2024
Budget allocation . M€ Budget allocation
Effort 493 p*m Effort
Effort 9 persons Full time equivalent

news

Behind the Scenes: Interview with Sophie, Pro...

2024-06-03

On May 27th, we took a significant step in wrapping up Project FLIX by filming an in-depth interview with Sophie Feuillastre,...

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Reflecting on Our 4th General Assembly of Oct...

2024-04-30

Six months ago, on October 19th and 20th, 2023, the FLIX project consortium convened for its highly anticipated 4th General...

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4th General Assembly is coming

2023-10-16

The 4th FLIX General Assembly is fast approaching. A two-day meeting of the project consortium members will begin in October...

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FLIX Press Release No 1

2023-06-12

We invite you to read the first issue of the press release.

We are currently in the 42nd month of the project and despite...

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2nd Mid-Term Review

2022-12-02

The online Mid-Term Review of the FLIX project will be held on 6 December 2022.

The purpose of the meeting is to review the...

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3rd General Assembly

2022-09-09

The next 3rd Flix General Assembly will take place in Aarhus (Denmark) on Wednesday 21 and Thursday 22, September 2022.

The...

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2nd FLIX Newsletter

2022-05-20

We are pleased to announce that the second issue of the FLIX newsletter has been published!


In this issue, you will find...

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New FLIX publication: Easy-to-Implement Hydro...

2022-04-01

The CEA partner has published a new scientific work related to the FLIX project: ‘Easy-to-Implement Hydrogen Isotope Exchange...

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2nd General Assembly

2021-12-01

The second year of the project is almost behind us. To look at the results of the project in more detail, on December 14,...

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The first FLIX Newsletter has just been published!

2021-04-30

The issue includes a short presentation of the main idea of the FLIX project and a description of the partners. It also...

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The fourth scientific publication for the FLI...

2021-04-09

The FLIX publication on nitrile isotope exchange has been accepted by the Journal of the American Chemical Society! 

Minghao...

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The third scientific publication for the FLIX...

2021-03-16

Marco Lepron, Marion Daniel-Bertrand, Gabriel Mencia, Bruno Chaudret, Sophie Feuillastre, Grégory Pieters...

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First review meeting with the European Commission

2021-03-10

On wednesday 17th of February, we held our first review meeting with the European Commission. It makes us feel proud that our...

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The second scientific publication for the FLI...

2021-02-25

Victor Babin, Alex Talbot, Alexandre Labiche, Gianluca Destro, Antonio Del Vecchio, Charles S. Elmore, Frederic Taran, Antoine...

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A first scientific publication for the FLIX p...

2021-02-11

Interested in C-H activation or deuteration? Then check out our latest study on manganese-catalyzed hydrogen isotope exchange...

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Institute of Life Sciences Frédéric Joliot ...

2020-10-06

Institute of Life Sciences Frédéric Joliot (CEA) talked about the launch of the European project FLIX in a Newsletter...

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FLIX at Nanocatalysis for Hydrogen Isotope Ex...

2020-09-17

On September 17, 2020, the Conference about Nanocatalysis for Hydrogen Isotope Exchange was held at Paris-Saclay University...

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Abstract published for ACS Fall 2020 Virtual ...

2020-08-17

FLIX project was in August at ACS Fall 2020 Virtual Meeting & Expo Conference. In the following link, you'll find the abstract...

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ACS Fall 2020 Virtual Meeting & Expo

2020-08-17

The FLIX partners attended to the ACS Fall 2020 Virtual Meeting & Expo Conference, which took place from August 17 to August...

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Kick-Off Meeting

2020-01-30

The kick-off meeting of FLIX project took place in Paris, on January 30, at CEA’s headquarters.
 

The FLIX project, funded  by...

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events

2024-04-08

EFMS-ACSMEDI Medicinal Chemistry Frontiers 2024

Poster presentation by Raji MOUNIR : EFMC-ACSMEDI MedChem Frontiers 2024, Utrecht (NL)

When:
From 08/04/2024 to 11/04/2024
Where: Vrije Universiteit Amsterdam, The Netherlands.

2024-03-07

Flow Chemistry Europe conference

Géllert Sipos presented 2 posters : Advancements in Isotopic Labeling: H/D Exchange on N-Heterocycles and the Development of a 13CO2 Generator & From on-DNA Chemistry to Continuous Flow: Development of a Novel Amidine Arylation Reaction

When:
07/03/2024 & 08/03/2024 
Where: Malaga, Spain

List of posters - Flow Chemistry Europe

2023-09-11

31st Colloquy on Organometallic Chemistry for Catalysis

Prof. Dr. Matthias Beller (Leibniz-Institut für Katalyse, Rostock) will give a presentation titled: “Catalysis – a key technology for sustainable chemistry and energy technologies”.

When:
11/09/2023 9:05-10:00 am
Where:
Lecture Hall H14 in building NW I, Universitätsstr. 30, 95447 Bayreuth, Germany

https://www.sustainable-chemistry-centre.uni-bayreuth.de/en/31st-Colloquy-on-Organometallic-Chemistry-for-Catalysis/index.html

2023-09-07

14th edition of the International School of Organometallic Chemistry (ISOC 2023)

Prof. Dr. Matthias Beller (Leibniz-Institut für Katalyse, Rostock) will give a presentation titled: “The importance of organometallic chemistry in Homogeneous and Heterogeneous catalysis”.

When:
7-11/09/2023 9:05-10:00 am
Where: Benedetto XIII Cultural Center, University of Camerino, Italy

2023-09-03

6th EuChemS Inorganic Chemistry Conference

Prof. Dr. Matthias Beller (Leibniz-Institut für Katalyse, Rostock) as a Plenary Lectures will give a presentation titled: “THE IMPORTANCE OF LIGANDS AND SUPPORTS FOR SUSTAINABLE CATALYSIS”.

When:
05/09/2023 Tuesday, 09:00 am
Where: TU Wien, Freihaus building, Wiedner Hauptstr. 8-10, A-1040 Vienna, Austria

https://eicc6.at/program/plenary-lectures

2023-07-03

Journées du GDR Synth-Flux 2023

Journées du GDR Synth-Flux 2023 Conference, 3-4 July 2023Paris (CNAM), France:

3 July 2023, 15:15 - 15:30 Flow-enabled quantitative and selective deuteration of amines - K. Tatoueix

4 July 2023, 10:05 - 10:20Continuous Flow Synthesis of Non-Symmetrical Ureas from CO2 (Amphi Abbé Grégoire) - A. Labiche

https://gdr-synthflux-2023.sciencesconf.org/

 

2022-10-17

Brazilian Meeting on Organic Synthesis (BMOS)

Professor Troels Skrydstrup from Aarhus University participated in the 18th Brazilian Meeting on Organic Synthesis conference. He presented a presentation entitled: "​Recent Developments in Carbonylation Chemistry".

The conference was held on 17-21 October 2022 in Tiradentes, Brazil.

2022-07-03

17th Belgian Organic Synthesis Symposium

Hans Christian Dahl Hammershøj, PhD Student from Aarhus University participated in the 17th Belgian Organic Synthesis Symposium. He presented the FLIX project during the poster session.

The Seminar took place from 3-8 July 2022 in Namur, Belgium.

2022-06-19

14th International Symposium on the Synthesis and Applications of Isotopically Labelled Compounds

Matthias Beller (Catalysis) will be attending in the 14th International Symposium on the Synthesis and Applications of Isotopically Labelled Compounds, Rayleigh, US

More information:

https://web.cvent.com/event/65d76618-d8fd-4df7-b18e-1d0de9c9461b/summary

2022-06-12

International Symposium on C–H Activation (ISCHA-6)

Matthias Beller (Catalysis) will be attending in the International Symposium on C–H Activation (ISCHA-6), in Germany,

More information: http://www.ackermann.chemie.uni-goettingen.de/ischa/ 

2021-10-21

Rennes Institute of Chemical Sciences conference

On Thursday, October 21, 2021 Gregory Pieters will give a presentation at the University of Rennes (Beaulieu Campus) under the title NANOCATALYZED HYDROGEN ISOTOPE EXCHANGE.
More information can be found at the link https://iscr.univ-rennes1.fr/gregory-pieters-conference

2021-10-06

2nd virtual IIS-CED Symposium

The second virtual IIS-CED conference on the 6/7th October. Young talents in Isotope Science presented their high-level scientific results. Catalysis as one of the consortium partners participated in this Symposium.

2021-10-06

IIS CED Virtual Conference - 2nd edition

Kevin Tatoueix (CEA) and Sara Kopf (Catalysis) will be attending a 2nd virtual conference called IIS CED Virtual Conference. We invite you to participate and establish contacts.

2021-09-22

Journée de Conférences Nanomatériaux

Gregory Pieters (CEA) will be a speaker at the Journée de Conférences Nanomatériaux conference. Gregory will give a talk entitled "Metallic nanoparticles and their use for radiolabelling".
If you are interested, please visit the website: https://www.escom.fr/agenda/colloque-nanoparticules-nanotechnologies-nanomateriaux/?cn-reloaded=1 

2021-09-14

SCI 2021, XXVII CONGRESSO NAZIONALE DELLA SOCIETÀ CHIMICA ITALIANA

Davide Audisio (CEA) will be attending a XXVII CONGRESSO NAZIONALE DELLA SOCIETÀ CHIMICA ITALIANA. We invite you to participate and establish contacts.

More information : https://www.sci2020.org/

Date: 14-23 September 2021

Location: Virtual conference

2020-09-17

Nanocatalysis for Hydrogen Isotope Exchange Conference (2020)

The Conference about Nanocatalysis for Hydrogen Isotope Exchange was held at Paris-Saclay University (ICSN) by Gregory Pieters (CEA).

2020-08-17

ACS Fall 2020 Virtual Meeting & Expo

Giving scientific professionals a platform to present, publish, discuss and exhibit the most exciting research discoveries and technologies in chemistry and its related disciplines. The meeting will facilitate networking opportunities, career development and placement, and provide companies an opportunity to exhibit products and services to a targeted audience.

documents

Newsletters

1st FLIX Newsletter

2nd FLIX Newsletter

FLIX Newsletter n°3

Newsletter - Institute of Life Sciences Frédéric Joliot (CEA) - Informations about Flix project

Other Scientific Publications

Publication 2021: A Nickel(II)-Mediated Thiocarbonylation Strategy for Carbon Isotope Labeling of Aliphatic Carboxamides - https://doi.org/10.1002/chem.202005261

Publication 2021: Davide AUDISIO & all - A Photochemical Strategy for Carbon Isotope Exchange with CO2

Publication 2021: Direct Carbon Isotope Exchange of Pharmaceuticals via Reversible Decyanation

Publication 2021: Investigation on the Stoichiometry of Carbon Dioxide in Isotope- Exchange Reactions with Phenylacetic Acids

Publication 2021: N-Heterocyclic Carbene-Based Iridium and Ruthenium/Iridium Nanoparticles for the Hydrogen Isotope Exchange Reaction through C–H Bond Activations - https://pubs.acs.org/doi/10.1021/acs.organomet.2c00288

Publication 2022: Parallel Screening with 14C-Labeled Carbon Dioxide: De-risking the Staudinger-Aza-Wittig Reaction - https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.202200133

4. Deliverables

D5.1 - Website and logo

5. Communication tools

FLIX Poster

Press release

FLIX Press Release No 1

Open-Access Scientific Publications

Publication 2021: Copper-catalysed low-temperature water–gas shift reaction for selective deuteration of aryl halides - Article in the Chemical Science journal: https://pubs.rsc.org/en/content/articlelanding/2021/SC/D1SC04259A

Publication 2021: Nanocatalyzed Hydrogen Isotope Exchange - https://pubs.acs.org/doi/full/10.1021/acs.accounts.0c00721

Publication 2021: Ruthenium-Catalyzed Deuteration of Aromatic Carbonyl Compounds with a Catalytic Transient Directing Group - https://doi.org/10.1002/chem.202100468

Publication 2021: Sara KOPF & all - Manganese-catalyzed selective C–H activation and deuteration by means of a catalytic transient directing group strategy

Publication 2022: Base-Mediated Remote Deuteration of N-Heteroarenes – Broad Scope and Mechanism - https://doi.org/10.1002/ejoc.202200204

Publication 2022: Easy-to-Implement Hydrogen Isotope Exchange for the Labeling of N‑Heterocycles, Alkylkamines, Benzylic Scaffolds, and Pharmaceuticals - https://pubs.acs.org/doi/10.1021/jacsau.1c00503?ref=pdf

Publication 2022: Easy-to-Implement Hydrogen Isotope Exchange for the Labeling of N‑Heterocycles, Alkylkamines, Benzylic Scaffolds, and Pharmaceuticals - https://pubs.acs.org/doi/pdf/10.1021/jacsau.1c00503

Publication 2022: Late-Stage Carbon-14 Labeling and Isotope Exchange: Emerging Opportunities and Future Challenges - https://pubs.acs.org/doi/10.1021/jacsau.2c00030?ref=pdf

Publication July 2023: Efficient C(sp3)􀀀 H Carbonylation of Light and Heavy Hydrocarbons with Carbon Monoxide via Hydrogen Atom Transfer Photocatalysis in Flow - https://onlinelibrary.wiley.com/doi/10.1002/anie.202308563

Publication May 2023: Unprecedented perspectives on the application of CinNapht fluorophores provided by a “late-stage” functionalization strategy - https://pubs.rsc.org/en/content/articlelanding/2023/sc/d3sc01365k

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