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FLIX FLow chemistry for Isotopic eXchange

FLIX is making the creation of isotope-labelled molecules easier, faster, and more effective with new generations of catalysts for isotope exchange along with flow chemistry. Success will have tremendous impact on fields from synthetic chemistry to biomedical diagnostics to materials research.

The ‘FLIX machinery’ will use a combination of specialized reactor modules operating under continuous flow conditions, either in closedloop or open systems for the on-line H/D, C-12/C-13, N-14/N-15 and methoxy group direct isotopic exchanges with an unprecedented efficacy and without any chemical alteration of the molecules.

The project’s objectives are to:

1) develop new generations of organometallic catalysts for isotopic exchange reactions;

2) screen catalysts for the isotopic exchange on a relevant portfolio of organic molecules in batch and flow chemistries and assess catalyst robustness;

3) devise and validate the ‘combinable isotope labeling’ concept;

4) design and build an adaptable multi-module machinery for combinable chemical exchange labeling.

FLIX synergistically associates the expertise and innovation potential of a mixed academic/industrial multidisciplinary consortium. The project is expected to have a multi-billion Euro positive impact on all sectors using stable isotopes in particular:

1) drug innovation, by accelerating preclinical studies, de-risking clinical trials and fostering the development of novel deuterated ‘heavy drugs’;

2) design of new tracers for diagnostic imaging with improved biological properties;

3) streamlining the production of multi-labeled complex molecules for NMR studies;

4) the development of novel isotopically-enriched materials.

partners / contact

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

[ CEA ]

France

SOPHIE FEUILLASTRE

SOPHIE FEUILLASTRE

National Institute of Applied Sciences of Toulouse

[ INSAT ]

France

BRUNO CHAUDRET

BRUNO CHAUDRET

Leibniz Institute of Catalysis

[ LIKAT ]

Germany

MATTHIAS BELLER

MATTHIAS BELLER

Aarhus University

[ AU ]

Denmark

TROELS SKYDSTRUP

TROELS SKYDSTRUP

Technical University Of Eindhoven

[ TUE ]

The Netherlands

TIMOTHY NOEL

TIMOTHY NOEL

ComInnex

[ COMINNEX ]

Hungary

GELLERT SIPOS

GELLERT SIPOS

Absiskey

[ ABSISKEY ]

France

Samy STROLA

Samy STROLA

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 862179 . This publication [communication] reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

graph - chart

Start 01/01/2020
5% 31/03/2020
End 31/12/2023
Budget allocation . M€ Budget allocation
Effort 493 p*m Effort
Effort 10 persons Full time equivalent

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Kick-Off Meeting

2020-01-30

The kick-off meeting of FLIX project took place in Paris, on January 30, at CEA’s headquarters.
 The FLIX project, fund...

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