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FLIX FLow chemistry for Isotopic eXchange

FLIX is making the creation of isotope-labelled molecules easier, faster, and more effective with new generations of catalysts for isotope exchange along with flow chemistry. Success will have tremendous impact on fields from synthetic chemistry to biomedical diagnostics to materials research.

The ‘FLIX machinery’ will use a combination of specialized reactor modules operating under continuous flow conditions, either in closedloop or open systems for the on-line H/D, C-12/C-13, N-14/N-15 and methoxy group direct isotopic exchanges with an unprecedented efficacy and without any chemical alteration of the molecules.

 

The project’s objectives are to:

1) develop new generations of organometallic catalysts for isotopic exchange reactions;

2) screen catalysts for the isotopic exchange on a relevant portfolio of organic molecules in batch and flow chemistries and assess catalyst robustness;

3) devise and validate the ‘combinable isotope labeling’ concept;

4) design and build an adaptable multi-module machinery for combinable chemical exchange labeling.

 

FLIX synergistically associates the expertise and innovation potential of a mixed academic/industrial multidisciplinary consortium. The project is expected to have a multi-billion Euro positive impact on all sectors using stable isotopes in particular:

1) drug innovation, by accelerating preclinical studies, de-risking clinical trials and fostering the development of novel deuterated ‘heavy drugs’;

2) design of new tracers for diagnostic imaging with improved biological properties;

3) streamlining the production of multi-labeled complex molecules for NMR studies;

4) the development of novel isotopically-enriched materials.

 
We look forward to begin the second year of the project with renovated strength and commitment.

partners / contact

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

[ CEA ]

France

SOPHIE FEUILLASTRE

SOPHIE FEUILLASTRE

National Institute of Applied Sciences of Toulouse

[ INSAT ]

France

BRUNO CHAUDRET

BRUNO CHAUDRET

Additional contact person: Dr. Guy Lippens, glippens@insa-toulouse.fr, Toulouse Biotechnology Institute Bio & Chemical Engineering

Leibniz Institute of Catalysis

[ LIKAT ]

Germany

MATTHIAS BELLER

MATTHIAS BELLER

Aarhus University

[ AU ]

Denmark

TROELS SKYDSTRUP

TROELS SKYDSTRUP

X-CHEM

[ X-CHEM ]

Hungary

GELLERT SIPOS

GELLERT SIPOS

Absiskey

[ ABSISKEY ]

France

Lauren DELAGE

Lauren DELAGE

Universiteit van Amsterdam

[ UVA ]

The Netherlands

TIMOTHY NOEL

TIMOTHY NOEL

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 862179 . This publication [communication] reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

graph - chart

Start 01/01/2020
95% 12/04/2024
End 30/06/2024
Budget allocation . M€ Budget allocation
Effort 493 p*m Effort
Effort 9 persons Full time equivalent

news

4th General Assembly is coming

2023-10-16

The 4th FLIX General Assembly is fast approaching. A two-day meeting of the project consortium members will begin in October...

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FLIX Press Release No 1

2023-06-12

We invite you to read the first issue of the press release.

We are currently in the 42nd month of the project and despite...

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2nd Mid-Term Review

2022-12-02

The online Mid-Term Review of the FLIX project will be held on 6 December 2022.

The purpose of the meeting is to review the...

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3rd General Assembly

2022-09-09

The next 3rd Flix General Assembly will take place in Aarhus (Denmark) on Wednesday 21 and Thursday 22, September 2022.

The...

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2nd FLIX Newsletter

2022-05-20

We are pleased to announce that the second issue of the FLIX newsletter has been published!


In this issue, you will find...

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New FLIX publication: Easy-to-Implement Hydro...

2022-04-01

The CEA partner has published a new scientific work related to the FLIX project: ‘Easy-to-Implement Hydrogen Isotope Exchange...

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2nd General Assembly

2021-12-01

The second year of the project is almost behind us. To look at the results of the project in more detail, on December 14,...

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The first FLIX Newsletter has just been published!

2021-04-30

The issue includes a short presentation of the main idea of the FLIX project and a description of the partners. It also...